Immunologic studies in asymptomatic hemophilia patients. Relationship to acquired immune deficiency syndrome (AIDS).

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Immunologic studies in asymptomatic hemophilia patients. Relationship to acquired immune deficiency syndrome (AIDS).

Asymptomatic hemophilia patients receiving Factor VIII concentrate were found to have normal natural killer (NK) cells and B cells, and an inverted T helper/suppressor ratio due to an increase in cells of T suppressor phenotype. In contrast, a hemophilia patient with acquired immune deficiency syndrome (AIDS) exhibited nonfunctional NK cells, low B cells, and an inverted T helper/suppressor rat...

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Acquired immune deficiency syndrome (AIDS) is a newly recognized disease of unknown etiology, characterized by deregulation of the cell-mediated immune function system and manifested by opportunistic infections, unusual neoplasms (particularly Kaposi's sarcoma) in previously healthy persons. Male homosexuals, drug addicts, Haitian immigrants, and hemophiliacs constitute the group at high risk o...

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Immunological studies in patients with acquired immune deficiency syndrome.

Defective cell-mediated immunity in the acquired immune deficiency syndrome (AIDS) is manifested by a reduction of T-helper (TH) cells and an increase of T-suppressor (T,) cells in peripheral blood, by loss of normal T-cell responses to mitogens and antigens in vivo and in vitro, and by increased susceptibility to opportunistic infections and malignancies.' Our immunological studies on a group ...

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As of March 31, 1987, the U.S. Centers for Disease Control had reported 33,350 cases of acquired immune deficiency syndrome. Yet by that date, physicians had actually diagnosed 42,670 cases. The difference arises from significant delays in the reporting of AIDS cases to public health authorities. An estimated 70% of cases are reported two or more months after diagnosis; about 23% are reported s...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 1983

ISSN: 0021-9738

DOI: 10.1172/jci110904